![]() From Rhodes, they became an active part of the trade in the Aegean sea, and at times harassed Turkish shipping in the Levant to secure control over the eastern Mediterranean. John, or Knights Hospitallers, had captured Rhodes in the early 14th century after the loss in 1291 of Acre, the last Crusader stronghold in Palestine. Despite very strong defenses, the walls were demolished over the course of six months by Turkish artillery and mines. ![]() The first siege in 1480 had been unsuccessful. The siege of Rhodes of 1522 was the second and ultimately successful attempt by the Ottoman Empire to expel the Knights of Rhodes from their island stronghold and thereby secure Ottoman control of the Eastern Mediterranean. John, including men from Spain, France, Germany, Italy, England, and Portugal) ![]() Ottoman supremacy secured over trade in the Eastern Mediterranean.Knights move initially to Sicily, but then to Malta, Gozo, and Tripoli. ![]()
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